E S S E NTIALS OF
Pharmacokinetics and Pharmacodynamics SECOND EDITION
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E S S E NTIALS OF
Pharmacokinetics and Pharmacodynamics SECOND EDITION
Thomas N. Tozer Malcolm Rowland
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Acquisitions Editor: Shannon Magee Product Development Editor: Stephanie Roulias Marketing Manager: Lisa Zoks Production Project Manager: Bridgett Dougherty Design Coordinator: Stephen Druding Manufacturing Coordinator: Margie Orzech Prepress Vendor: S4Carlisle Publishing Services 2nd edition Copyright © 2016 Wolters Kluwer. Copyright © 2006 by Lippincott Williams & Wilkins. All rights reserved. This book is protected by copyright. No part of this book may be reproduced or transmitted in any form or by any means, including as photocopies or scanned-in or other electronic copies, or utilized by any information storage and retrieval system without written permission from the copyright owner, except for brief quotations embodied in critical articles and reviews. Materials appearing in this book prepared by individuals as part of their official duties as U.S. government employees are not covered by the above-mentioned copyright. To request permission, please contact Wolters Kluwer at Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103, via email at
[email protected], or via our website at lww.com (products and services). 9 8 7 6 5 4 3 2 1 Printed in China Library of Congress Cataloging‐in‐Publication Data Tozer, Thomas N., author. [Introduction to pharmacokinetics and pharmacodynamics] Essentials of pharmacokinetics and pharmacodynamics / Thomas N. Tozer, Malcolm Rowland. ‐‐ Second edition. p. ; cm. Preceded by Introduction to pharmacokinetics and pharmacodynamics : the quantitative basis of drug therapy / Thomas N. Tozer, Malcolm Rowland. c2006. Includes index. ISBN 978‐1‐4511‐9442‐5 I. Rowland, Malcolm, author. II. Title. [DNLM: 1. Pharmacokinetics. 2. Dose‐Response Relationship, Drug. 3. Drug Therapy‐‐methods. 4. Pharmaceutical Preparations‐‐administration & dosage. QV 38] RM301.5 615’.7‐‐dc23 2015021592 This work is provided “as is,” and the publisher disclaims any and all warranties, express or implied, including any warranties as to accuracy, comprehensiveness, or currency of the content of this work. This work is no substitute for individual patient assessment based upon healthcare professionals’ examination of each patient and consideration of, among other things, age, weight, gender, current or prior medical conditions, medication history, laboratory data and other factors unique to the patient. The publisher does not provide medical advice or guidance and this work is merely a reference tool. Healthcare professionals, and not the publisher, are solely responsible for the use of this work including all medical judgments and for any resulting diagnosis and treatments. Given continuous, rapid advances in medical sci