Cell Biology : Translational Impact In Cancer Biology And Bioinformatics

Cell Biology Translational Impact in Cancer Biology and Bioinformatics Maika G. Mitchell AMSTERDAM l BOSTON l HEIDELBERG l LONDON NEW YORK l OXFORD l PARIS l SAN DIEGO SAN FRANCISCO l SINGAPORE l SYDNEY l TOKYO Academic Press is an imprint of Elsevier Academic Press is an imprint of Elsevier 125 London Wall, London EC2Y 5AS, UK 525 B Street, Suite 1800, San Diego, CA 92101-4495, USA 50 Hampshire Street, Cambridge, MA 02139, USA The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, UK Copyright Ó 2016 Elsevier Inc. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publisher’s permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions. This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein). Notice Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary. Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility. To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assume any liability for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein. ISBN: 978-0-12-801853-8 British Library Cataloging-in-Publication Data A catalog record for this book is available from the British Library Library of Congress Cataloging-in-Publication Data A catalog record for this book is available from the Library of Congress For information on all Academic Press publications visit our website at www.elsevier.com Acquisition Editor: Shirley Decker-Lucke Editorial Project Manager: Halima Williams Production Project Manager: Karen East and Kirsty Halterman Designer: Victoria Pearson Typeset by TNQ Books and Journals www.tnq.co.in Printed and bound in the United States of America Dedication For those of you born with the fire and curiosity for science, keep the flame alive. Chapter 1 Clinical Utility/Relevance of Cell Biology Techniques WHAT IS CLINICAL UTILITY/RELEVANCE The research activities in cell biology are directed toward understanding