Natural Products-drug Discovery And Therapeutic Medicine

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Although large drug companies are now concentrating on cheap synthetics as much as they are on natural compounds, the natural compounds still hold great promise in antibiotic resistance, in treating new diseases and old diseases not treatable by other means, and in dealing with the toxicity of some of those cheap synthetics. Reviewing both basic and applied aspects of natural products, this collection of 16 articles addresses fundamental issues, strategies such as automated analyses of HPLC profiles of microbial extracts, specific groups of drugs such as those to fight cancer, microbial diversity, including accessing the genomes of uncultivated microbes for novel products, and specific sources such as those from marine actinomycetes, rainforest endophytes, and traditional medicine harvesting in such places as Ecuador.

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Natural Products Drug Discovery and Therapeutic Medicine Edited by by Edited Lixin Zhang Arnold L. Demain Natural Products Natural Products Drug Discovery and Therapeutic Medicine Edited by Lixin Zhang, PhD Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China, and SynerZ Pharmaceuticals Inc., Lexington, MA Edited by Arnold L. Demain, PhD Charles A. Dana Research Institute (R.I.S.E.), Drew University, Madison, NJ © 2005 Humana Press Inc. 999 Riverview Drive, Suite 208 Totowa, NJ 07512 www.humanapress.com All rights reserved. No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise without written permission from the Publisher. The content and opinions expressed in this book are the sole work of the authors and editors, who have warranted due diligence in the creation and issuance of their work. The publisher, editors, and authors are not responsible for errors or omissions or for any consequences arising from the information or opinions presented in this book and make no warranty, express or implied, with respect to its contents. Production Editor: Tracy Catanese Cover design by Patricia F. Cleary For additional copies, pricing for bulk purchases, and/or information about other Humana titles, contact Humana at the above address or at any of the following numbers: Tel.: 973-256-1699; Fax: 973-256-8341; E-mail: [email protected] or visit our website: www.humanapress.com This publication is printed on acid-free paper. ∞ ANSI Z39.48-1984 (American National Standards Institute) Permanence of Paper for Printed Library Materials. Photocopy Authorization Policy: Authorization to photocopy items for internal or personal use, or the internal or personal use of specific clients, is granted by Humana Press Inc., provided that the base fee of US $30.00 per copy is paid directly to the Copyright Clearance Center at 222 Rosewood Drive, Danvers, MA 01923. For those organizations that have been granted a photocopy license from the CCC, a separate system of payment has been arranged and is acceptable to Humana Press Inc. The fee code for users of the Transactional Reporting Service is: [1-58829-383-1/05 $30.00]. Printed in the United States of America. 10 9 8 7 6 5 4 3 2 1 eISBN: 1-59259-920-6 Library of Congress Cataloging-in-Publication Data Natural products : drug discovery and therapeutic medicine / edited by Lixin Zhang, Arnold L. Demain. p. ; cm. Includes bibliographical references and index. ISBN 1-58829-383-1 (alk. paper) 1. Pharmacognosy. [DNLM: 1. Drug Design. 2. Pharmacognosy. 3. Biological Factors--therapeutic use. 4. Biological Products--therapeutic use. 5. Pharmacogenetics. QV 752 N285 2005] I. Zhang, Lixin. II. Demain, A. L. (Arnold L.), 1927RS
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