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Of the hundreds of thousands of compounds synthesized each year, most have almost no chance of becoming drugs. This problem exists because most molecules lack the drug-like properties necessary to enable them to be effective in vivo. To address this issue, Alex Avdeef's Absorption and Drug Development shows the reader how to examine a compound's pharmaceutical properties, emphasizing oral absorption. This book explains the different physicochemical methods currently used to analyze drug candidates and how to interpret these methods. Also included are physicochemical data for over 200 commercial drugs. With over 600 references and 100 drawings, this book is an excellent resource for the practical pharmaceutical chemist and those seeking a better understanding of physicochemical measurements.
E-Book Content
ABSORPTION AND DRUG DEVELOPMENT
ABSORPTION AND DRUG DEVELOPMENT Solubility, Permeability, and Charge State
ALEX AVDEEF pION, Inc.
A JOHN WILEY & SONS, INC., PUBLICATION
Copyright # 2003 by John Wiley & Sons, Inc. All rights reserved. Published by John Wiley & Sons, Inc., Hoboken, New Jersey. Published simultaneously in Canada. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, scanning, or otherwise, except as permitted under Section 107 or 108 of the 1976 United States Copyright Act, without either the prior written permission of the Publisher, or authorization through payment of the appropriate per-copy fee to the Copyright Clearance Center, Inc., 222 Rosewood Drive, Danvers, MA 01923, 978-750-8400, fax 978-750-4470, or on the web at www.copyright.com. Requests to the Publisher for permission should be addressed to the Permissions Department, John Wiley & Sons, Inc., 111 River Street, Hoboken, NJ 07030, (201) 748-6011