Anesthesia For The New Millennium: Modern Anesthetic Clinical Pharmacology

ANESTHESIA FOR THE NEW MILLENNIUM DEVELOPMENTS IN CRITICAL CARE MEDICINE AND ANESTHESIOLOGY Volume 34 The titles published in this series are listed at the end o/this volume. ANESTHESIA FOR THE NEW MILLENNIUM Modern Anesthetic Clinical Pharmacology edited by THEODORE H. STANLEY ANO TALMAGE O. EGAN Department of AfU!SIMSiology, Tiu Utt;versityo/UlIJh Medical Schoof, Salt lAk Ciry, Utah, U.sA . SPRINGER'SCIENCE+BUSINESS MEDIA, B.V. A C.I.P. Catalogue record for this book is available from the Library of Congress. ISBN 978-94-010-5935-0 ISBN 978-94-011-4566-4 (eBook) DOI 10.1007/978-94-011-4566-4 Printed on acid-free paper All Rights Reserved ©1999 Springer Science+Business Media Dordrecht Originally published by Kluwer Academic Publishers in 1999 Softcover reprint of the hardcover 1st edition 1999 No part ofthe material protected by this copyright notice may be reproduced or utilized in any fonn or by any means, electronic or mechanical, including photocopying, recording or by any information storage and retrieval system, without written permission from the copyright owner. TABLE OF CONTENTS Preface ix List of Contributors xi NEW PHARMACOKINETIC CONCEPTS Peter 5.A. Glass THE BIOPHASE CONCEPT 13 Donald R. 5tanski BANDEDNESS IN ANESTHETIC PHARMACOLOGY 19 Talmage D. Egan ANESTHETICS AND VENTILATORY DRIVE 31 Peter L. Bailey WHEN DOES THE INFANT MATURE 49 PHARMACOLOGICALLY"? Dennis M. Fisher BRAIN IMAGING FOR ELUCIDATING MECHANISMS 55 OF ANESTHESIA Pierre Fiset IS PHARMACOKINETICS RELEVANT? 63 Dennis M. Fisher PHYSIOLOGIC VS. PHARMACOLOGIC SLEEP 71 Pierre Fiset AW ARENESS UNDER ANESTHESIA: CURRENT UNDERSTANDING Peter 5. 5ebel 77 vi DEPTH OF ANESTHESIA MONITORING TECHNIQUES: 85 AN OVERVIEW DonaLd R. Stanski BISPECTRAL INDEX MONITORING TECHNOLOGY: AN OVERVIEW 91 CarL E. Rosow BISPECTRAL MONITORING TECHNOLOGY: 99 CLINICAL APPLICATIONS Peter S. SebeL TARGET CONTROLLED DRUG DELIVERY IN 105 ANESTHESIOLOGY Steven E. Kern THE PRINCIPLES OF TOTAL INTRA VENOUS ANESTHESIA (TIV A) 117 Peter S. A. Glass TRANSMUCOSAL AND OTHER NEW DRUG 137 DELIVERY TECHNOLOGIES Theodore Ii. Stanley A CONCEPT FOR ASSESSING ANESTHETIC INTERACTIONS 153 Igor Kissin DRUG INTERACTIONS: 165 OPIOIDS AND SEDATIVE HYPNOTICS Carl Rosow INTERACTIONS: GENERAL PRINCIPLES 171 Igor Kissin DRUG INTERACTIONS: OPIOIDS AND INHALED ANESTHETICS Peter S. A. Glass 181 vii AN UPDATE ON THE CLINICAL USE OF PROPOFOL 195 Paul F. White KINETIC CONSIDERATIONS IN THE SELECTION OF AN INHALED ANESTHETIC