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Animal cell technology is a growing discipline of cell biology which aims not only to understand structures, functions and behaviors of differentiated animal cells but also to ascertain their abilities to be used in industrial and medical purposes. The goal of animal cell technology includes accomplishments of clonal expansion of differentiated cells with useful ability, optimization of their culture conditions, modulation of their ability to produce medically and pharmaceutically, important proteins, and the application of animal cells to gene therapy and artificial organs. This volume gives the readers a complete review of present state of the art in Japan. The Proceedings will be useful for cell biologists, biochemists, molecular biologists, immunologists, biochemical engineers and other disciplines related to animal cell culture, working in either academic environments or in biotechnology and pharmaceutical industries.
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ANIMAL CELL TECHNOLOGY: CHALLENGES FOR THE 21ST CENTURY
JAACT/ESACT’98 Organizing Committee Meeting Chairman:
R. Sasaki
(Japan)
Meeting Secretaries:
K. Ikura (Japan) M. Nagao (Japan) S . Masuda (Japan)
Organizing Boards: T. Amachi (Japan) M. Carrondo (Portugal)
A. Ametani (Japan) S . Dosako (Japan)
K. Aramaki (Japan) A. Enomoto (Japan)
T. Fujimori (Japan)
Y. Fuke (Japan)
T. Furudera (Japan)
T. Fushiki (Japan)
B. Griffiths (UK)
S. Hashizume (Japan)
H. Hoshi (Japan)
S. Iijima (Japan)
K. Ikura (Japan)
K. Inouye (Japan)
K. Issiki (Japan)
Y. Ikeda (Japan)
Y. Ito (Japan) K. Kawamura (Japan) C. MacDonald (UK) R. Matsuno (Japan)
S. Kaminogawa (Japan) Y. Kitagawa (Japan) S . Masuda (Japan) O. Merten (France)
T. Kawada (Japan) J. Lehmann (Germany) T. Matsuda (Japan) K. Nagai (Japan)
K. Nagaike (Japan) R. Sasaki (Japan)
M. Nagao (Japan) T. Sato (Japan)
H . Ohigashi (Japan) H . Sawada (Japan)
K. Shin (Japan)
K. Shinohara (Japan)
S. Shirahata (Japan)
Y. Shirai (Japan) M. Tanokura (Japan) K. Yagasaki (Japan)
T. Suzuki (Japan) K. Ueda (Japan) M. Yoshikawa (Japan)
E. Suzuki (Japan) J. Wérenne (Belgium)
Animal Cell Technology: Challenges for the 21st Century Proceedings of the joint international meeting of the Japanese Association for Animal Cell Technology (JAACT) and the European Society for Animal Cell Technology (ESACT) 1998, Kyoto, Japan edited by
Kouji Ikura
Masaya Nagao
Seiji Masuda and
Ryuzo Sasaki
KLUWER ACADEMIC PUBLISHERS New York, Boston, Dordrecht, London, Moscow
eBook ISBN: Print ISBN:
0-306-46869-7 0-792-35805-8
©2002 Kluwer Academic Publishers New York, Boston, Dordrecht, London, Moscow
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Contents Preface
xiii I. Asian Biotechnology in Future
The role of Hong Kong SAR in the development of biotechnology industry in China A. Y. Chang
1
II.Cell Culture and Engineering
Increase in intracellular calcium influx enhances monoclonal antibody productivity S.-H. Park, J.-S. Park, M.-H. Nam
5
Energy metabolism and antibody production based on flux analysis in hybridoma T. Omasa, T. Iemara, K, Furuichi, Y. Katakura, M. Kishimoto, K. Suga
11
Transient transfection i