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Perhaps no scientific field in recent years has gained in techniques and applications as much as molecular biology, and it is certainly no ex aggeration to·say that among all the applications of molecular biology, hematology in general, and hemopoiesis in particular, have benefited most. Owing to the applications of molecular biology, we now live in a golden era of hemopoiesis. Our understanding of the intricate regulatory system in hemopoiesis has vastly expanded. The potential for future exploration is ever expanding, and finally, the possibility of gene manipulation, has provided the promise of fundamental treatment and "cure" of many genetic disorders involving hemopoietic cells. In the ambiance of this rapidly moving scientific era, the necessity for review of what is being accomplished and where the technical potential is taking us needs no argument. This volume presents the proceedings of the third annual symposium on the Molecular Biology of Hemopoiesis, held in the Rye Town Hilton, New York, November 6 and 7, 1987, under the auspices of New York Medical College, Valhalla, New York. The fact that this was the third regular symposium covering this area in itself testifies to a need for exchange of the rapidly developing knowledge in this area. But this third symposium also coincided with the centennial of the National Institutes of Health and consequently the symposium was dedicated to this festive occasion.
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MOLECULAR BIOLOGY OF HEMOPOIESIS
ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY Editorial Board: NATHAN BACK, State University of New York at Buffalo IRUN R. COHEN, The Weizmann Institute of Science DAVID KRITCHEVSKY, Wistar Institute ABEL LAJTHA, N. S. Kline Institute for Psychiatric Research ROOOLFO PAOLETTI, University of Milan
Recent Volumes in this Series Volume 234 BIOLOGY OF GROWTH FACTORS: Molecular Biology, Oncogenes, Signal Transduction, and Clinical Implications Edited by Jeffrey E. Kudlow, David H. MacLennan, Alan Bernstein, and Avrum I. Gotlieb Volume 235 CENTRAL DI DOPAMINE RECEPTORS Edited by Menek Goldstein, Kjell Fuxe, and Irving Tabachnick Volume 236 NEURORECEPTORS AND SIGNAL TRANSDUCTION Edited by Shozo Kito, Tomio Segawa, Kinya Kuriyama, Masaya Tohyama, and Richard W. Olsen Volume 237 HISTOPHYSIOLOGY OF THE IMMUNE SYSTEM: The Life History, Organization, and Interactions of Its Cell Populations Edited by Sigbj0rn Fossum and Bent Rolstad Volume 238 BIOTECHNOLOGICAL APPLICATIONS OF LIPID MICROSTRUCTURES Edited by Bruce Paul Gaber, Joel M. Schnur, and Dennis Chapman Volume 239 HOST DEFENSES AND IMMUNOMODULATION TO INTRACELLULAR PATHOGENS Edited by Toby K. Eisenstein, Ward E. Bullock, and Nabil Hanna Volume 240 PROTEASES: Potential Role in Health and Disease II Edited by Walter H. Hor! and August Heidland Volume 241 MOLECULAR BIOLOGY OF HEMOPOIESIS Edited by Mehdi Tavassoli, Esmail D. Zanjani, Joao L. Ascensao, Nader G. Abraham, and Alan S. Levine
A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediately upon pUblication. Volumes are billed only upon actual shipment. For further information please contact the publisher.
MOLECULAR BIOLOGY OF HEMOPOIESIS Edited by
Mehdi Tavassoli Veterans Administration Medical Center University of Mississippi Jackson, Mississippi
Esmail D. Zanjani Veterans Administration Medical Center University of Nevada Reno, Nevada
Joao L. Ascensao and Nader G. Abraham New York Medical College Valhalla, New York
and
Alan S. Levine National Heart, Lung, and Blood Institute DiVision of Blood Diseases and Resources Bethesda, Maryland
PLENUM PRESS • NEW YORK AND LONDON
Library of Congress Cataloging in Publication Data Symposium on Molecular Biology of Hemopoiesis (3rd: 1987: Rye Brook, N.Y.) Molecular