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Specialist Periodical Reports provide systematic and detailed review coverage of progress in the major areas of chemical research. Written by experts in their specialist fields the series creates a unique service for the active research chemist, supplying regular critical in-depth accounts of progress in particular areas of chemistry. In an ever-increasing domain of activity Amino Acids Peptides and Proteins provides an annual compilation of the world's research effort into this important area of biological chemistry. Volume 31 provides a review of literature published during 1998. Comprising a comprehensive review of significant developments at this biology/chemistry interface each volume opens with an overview of amino acids and their applications. Work on peptides is reviewed over several chapters ranging from current trends in their synthesis and conformational and structural analysis to peptidomimetics and the discovery of peptide-related molecules in nature. The application of advanced techniques in structural elucidation is incorporated into all chapters whilst periodic chapters on metal complexes of amino acids, peptides and beta-lactams extend the scope of coverage. Efficient searching of specialist topics is facilitated by the sub-division of chapters into discrete subject areas allowing annual trends to be monitored. All researchers in the pharmaceutical and allied industries and at the biology/chemistry interface in academia will find this an indispensable reference source.
E-Book Content
A Specialist Periodical Report
Amino Acids, Peptides and Proteins
Volume 31
A Review of the Literature Published during 1998 Senior Reporter J.S. Davies, University of Wales, Swansea, UK Reporters G.C. Barrett, Oxford, UK A. Dutta, AstraZeneca, Macclesfield, UK D.T. Elmore, University of Oxford, UK E . Farkas, Lajos Kossuth University, Debrecen, Hungary J.A. Littlechild, University of Exeter, UK I. Sovago, Lajos Kossuth University, Debrecen, Hungary
RSeC ROYAL SOCIETY OF CHEMISTRY
ISBN 0-85404-227-X ISSN 1361-5904 Copyright
0The Royal Society of Chemistry 2000
All Rights Reserved Apart from any fair dealingfor the purposes of research or private study, or criticism or review as permitted under the terms of the UK Copyright, Designs and Patents Act, 1988, this publication may not be reproduced, stored or transmitted, in any form or by any means, without the prior permission in writing of The Royal Society of Chemistry, or in the case of reprographic reproduction only in accordance with the terms of the licences issued by the Copyright Licensing Agency in the UK, or in accordance with the terms of the licences issued by the appropriate Reproduction Rights Organization outside the UK.Enquiries concerning reproduction outside the terms stated here should be sent to The Royal Society of Chemistry at the address printed on this page. Published by The Royal Society of Chemistry Thomas Graham House, Science Park, Milton Road, Cambridge CB4 OWF. U K For further information see our web site at www.rsc.org Typeset by Computape (Pickering) Ltd, Pickering, North Yorkshire, UK Printed by Athenaeum Press Ltd, Gatehead, Tyne and Wear, UK
The task set for the authors in this volume was to survey the world’s peptide/ protein literature to the end of 1998. The emphasis, as always, in this series has been to review as comprehensively as possible the specialist papers produced in each area, but the expansion in the volume of literature usually means that individual Reporters have to highlight the most significant work, at the expense of the routine. Regular readers of these annual volumes often have the chance of monitoring the ebb and flow of various specialities, and occasionally an area which has been the subjected of many annual progress reports experiences a quantum leap into fru