Neurogenic Inflammation In Health And Disease

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Morphological and functional studies revealed a complex system of primary sensory neurons which parallels the autonomic nervous system not only in its extent, but probably also in its significance. Neuropeptides released from activated nociceptive afferent nerves play a pivotal role in inflammatory reactions and pain, significantly modulate cardiac, vascular, respiratory, gastrointestinal and immune functions and influence the protective, restorative and trophic functions of somatic and visceral tissues. Several chapters of the book deal with the therapeutic potential of a new class of putative pain relieving agents acting through TRPV1, the capsaicin/vanilloid receptor, a specific ion channel which transmits pain. *Neurogenic inflammation in historical perspective*Cardiac protection by nociceptive afferents*Molecular mechanisms of nociception*Sensory mechanisms in migraine pathophysiology*Vagal signalling of visceral inflammation*Neurogenic mechanisms in arthritis*Therapeutic implications of vanilloid-type compounds

E-Book Content

Neurogenic Inflammation in Health and Disease Neuroimmune Biology, Volume 8 Neuroimmune Biology Series Editor I. Berczi Advisory Board B.G. Arnason, Chicago, IL E. Arzt, Buenos Aires, Argentina P.J. Ba`rnes, London, UK T. Bartfai, La Jolla, CA L. Berto´k, Budapest, Hungary H.O. Besedovsky, Marburg, Germany J. Bienestock, Hamilton, Canada C.M. Blatteis, Memphis, TN J. Buckingham, London, UK Ch. Chawnshang, Rochester, NY M. Dardenne, Paris, France R.M. Gorczynski, Toronto, Canada C. Heijnen, Utrecht, The Netherlands T. Hori, Fukuoka, Japan E.A. Korneva, St. Petersburg, Russia K. Kovacs, Toronto, Canada L. Matera, Turin, Italy H. Ovadia, Jerusalem, Israel C.P Phelps, Tampa, FL L.D. Prockop, Tampa, FL R. Rapaport, New York, NY K. Skwarlo-Sonta, Warsaw, Poland E.M. Sternberg, Bethesda, MD D.W. Talmage, Denver, CO S. Walker, Columbia, MO A.G. Zapata, Madrid, Spain Neurogenic Inflammation in Health and Disease Volume Editor Ga´bor Jancso´ Department of Physiology, University of Szeged, Hungary AMSTERDAM  BOSTON  HEIDELBERG  LONDON  NEW YORK  OXFORD PARIS  SAN DIEGO  SAN FRANCISCO  SINGAPORE  SYDNEY  TOKYO Elsevier Radarweg 29, PO Box 211, 1000 AE Amsterdam, The Netherlands Linacre House, Jordan Hill, Oxford OX2 8DP, UK 32 Jamestown Road, London, NWI 7BY, UK The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, UK First edition 2009 Copyright  2009 Elsevier B.V. All rights reserved No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means electronic, mechanical, photocopying, recording or otherwise without the prior written permission of the publisher Permissions may be sought directly from Elsevier’s Science & Technology Rights Department in Oxford, UK: phone (+44) (0) 1865 843830; fax (+44) (0) 1865 853333; email: [email protected] Alternatively you can submit your request online by visiting the Elsevier web site at http://elsevier.com/locate/permissions, and selecting Obtaining permission to use Elsevier material Notice No responsibility is assumed by the publisher for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions or ideas contained in the material herein. Because of rapid advances in the medical sciences, in particular, independent verification of diagnoses and drug dosages should be made British Library Cataloguing in Publication Data A catalogue record for this book is available from the British Library Library of Congress Cataloging-in-Publication Data A catalog record for this book is available fr
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