Statistics for Biology and Health Series Editors W. Wong, M. Gail, K. Krickeberg, A. Tsiatis, J. Samet
Robert Gentleman Vincent J. Carey Wolfgang Huber
Rafael A. Irizarry Sandrine Dudoit
Editors
Bioinformatics and Computational Biology Solutions Using R and Bioconductor With 128 Illustrations
Editors Robert Gentleman Program in Computational Biology Division of Public Health Sciences Fred Hutchinson Cancer Research Center 1100 Fairview Ave. N, M2-B876 PO Box 19024 Seattle, Washington 98109-1024 USA
[email protected] Wolfgang Huber European Bioinformatics Institute European Molecular Biology Laboratory Cambridge, CB10 1SD UK
[email protected]
Series Editors Wing Wong Department of Statistics Stanford University Stanford, CA 94305 USA A. Tsiatis Department of Statistics North Carolina State University Raleigh, NC 27695 USA
Vincent J. Carey Channing Laboratory Brigham and Women’s Hospital Harvard Medical School 181 Longwood Ave Boston MA 02115 USA
[email protected]
Rafael A. Irizarry Department of Biostatistics Johns Hopkins Bloomberg School of Public Health 615 North Wolfe Street Baltimore, MD 21205 USA
[email protected]
Sandrine Dudoit Division of Biostatistics School of Public Health University of California, Berkeley 140 Earl Warren Hall, #7360 Berkeley, CA 94720-7360 USA
[email protected]
M. Gail National Cancer Institute Rockville, MD 20892 USA
K. Krickeberg Le Cha¨telet F-63270 Manglieu France
J. Samet Department of Epidemiology School of Public Health Johns Hopkins University 615 Wolfe Street Baltimore, MD 21205 USA
Library of Congress Control Number: 2005923843 ISBN-10: 0-387-25146-4 ISBN-13: 978-0387-25146-2
Printed on acid-free paper.
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Preface During the past few years, there have been enormous advances in genomics and molecular biology, which carry the promise of understanding the functioning