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ADVANCES
IN CANCER RESEARCH VOLUME 20
Contributors to This Volume Heinz Bauer Max
Michael H. Levy
M. Burger
G. J. V. Nostal
P. 1. Grover
Annette M. C. Rapin
Sir Alexander Haddow
P. Sims
E. Frederick Wheelock
ADVANCES IN CANCER RESEARCH Edited by
GEORGE KLEIN Department of Tumor Biology Karolinska lnstitutet Stockholm, Sweden
SIDNEY WEINHOUSE Fels Research Institute Temple University Medical School Philadelphia, Pennsylvania
Consulting Editor
ALEXANDER HADDOW Chester Beatty Research Institute Institute of Cancer Research Royal Cancer Hospital London, England
Volume
20-7974
ACADEMIC PRESS
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London
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LIBRARY OF CONGRESS CATALOG CARD NUMBER:52-1 3360 ISBN 0- 12-006620-3 PRINTED I N T H E UNITED STATES OF AMERICA
CONTENTS CONTRIBUTORS TO VOLUME20
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ix
Tumor Cell Surfaces: General Alterations Detected by Agglutinins
ANNETTEM. C. RAPINAND MAX M. BURGER
I. Introduction . . . . . . . . . . . . . 11. Correlation between Lectin Binding, Agglutinability, and the Transformed State . . . . . . . . . . . 111. Discussion on Possible Mechanisms of Agglutination . . . . IV. Relevance of Cell Surface Alterations in Growth Control . . . , V. Surface Changes in the Cell Cycle . . . . . . . . VI. Survey of Chemical Differences Found in the Surfaces of Transformed . . . . . . . . . . . . . . Cells VII. Conclusions . . . . . . . . . . . . . References . . . . . . . . . . . . .
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1 4 20 43 66 71 77 78
Principles of Immunological Tolerance and lmmunocyte Receptor Blockade
G. J. V. NOSSAL
I. Introduction . . . . . . . . . . . . . 11. Background Concepts about the Mechanism of Action of Antigens . 111. Possible Levels for Immunity-Tolerance Signal Discrimination . . IV. Tolerance Induced in T and B Lymphocytes by Soluble, Oligovalent . . . . . . . . . . . . . Antigens . V. Tolerance Induced in T and B Lymphocytes by Antigens Possessing Multiple Repeating Determinants . . . . . . . . . VI. Tolerance in T and B Lymphocytes Produced by Antigen-Antibody Complexes . . . . . . . . . . . . . VII. Effector Cell Blockade by Multivalent Antigens . . . . . VIII. Suppressor T Cells . . . . . . . . . . . . IX. Relevance of Tolerance and Effector Cell Blockade to Cancer . . X. Summary . . . . . . . . . . . . . . References . . . . . . . . . . . . .
93 95 99 103 108 113 116 119 122 125 126
The Role of Macrophages in Defense against Neoplastic Disease
MICHAELH. LEVYAND E. FREDERICK WHEELOCK
I. Introduction . . . . . 11. RES and Tumor Resistance . . 111. Macrophages and Tumor Resistance IV. Conclusion . . . . . References . . . . . V
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131 134 137 155 156
vi
CONTENTS
Epoxides in Polycyclic Aromatic Hydrocarbon Metabolism and Carcinogenesis
P. Sixrs
.
AND
P. L. GROVER
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