Immunology Of Pregnancy (medical Intelligence Unit)

MEDICAL INTELLIGENCE UNIT Immunology of Pregnancy Gil Mor, M.D., Ph.D. Department of Obstetrics and Gynecology Reproductive Immunology Unit Yale University School of Medicine New Haven, Connecticut, U.S.A. L A N D E S B I O S C I E N C E / EUREKAH.COM GEORGETOWN, TEXAS U.S.A. S P R I N G E R SCIENCE+BUSINESS M E D I A NEW YORK, NEW YORK U.S.A. IMMUNOLOGY OF PREGNANCY Medical Intelligence Unit Landes Bioscience / Eurekah.com Springer Science+Business Media, Inc. ISBN: 0-387-30612-9 Printed on acid-free paper. Copyright ©2006 Eurekah.com and Springer Science+Business Media, Inc. All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher, except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in the publication of trade names, trademarks, service marks and similar terms even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the authors, editors and publisher believe that drug selection and dosage and the specifications and usage of equipment and devices, as set forth in this book, are in accord with current reccrmmendations and practice at the time of publication, they make no warranty, expressed or implied, with respect to material described in this book. In view of the ongoing research, equipment development, changes in governmental regulations and the rapid accumulation of information relating to the biomedical sciences, the reader is urged to carefully review and evaluate the information provided herein. Springer Science+Business Media, Inc., 233 Spring Street, New York, New York 10013, U.S.A. http://www.springer.com Please address all inquiries to the Publishers: Landes Bioscience / Eurekah.com, 810 South Church Street, Georgetown, Texas 78626, U.S.A. Phone: 512/ 863 7762; FAX: 512/ 863 0081 http://www.eurekah.com http://www.landesbioscience.com Printed in the United States of America. 9 8 7 6 5 4 3 2 1 Library of Congress Cataloging-in-Publication Data Immunology of pregnancy / [edited by] Gil Mor. p. ; cm. ~ (Medical intelligence unit) Includes bibliographical references and index. ISBN 0-387-30612-9 (alk. paper) 1. Pregnancy—Immunological aspects. [DNLM: 1. Pregnancy-immunology. 2. Immunity-Pregnancy. W Q 200 13272 2006] I. Mor, Gil. II. Title. Ill, Series: Medical intelligence unit (Unnumbered : 2003) RG557.I48 2006 6l8.2'079-dc22 2005030784 To my wife Anette for her unconditional love and support CONTENTS Preface Immunology of Implantation: An Introduction GilMor Pregnancy Represents an Allograft General Concepts of Immunology Maternal Immune Response to the Trophoblast The Role of the Innate Immune System in Pregnancy Apoptosis and Implantation 1. Evolution of the Mammalian Reproductive Tract and Placentation Susan Richman and