ADVANCES IN CANCER RESEARCH VOLUME 41 Contributors to This Volume Magnus Bjorkholm David Harnden Tim Byers Goran Holm Bernard Dutrillaux Nancy E. Hynes Terry Featherstone Leandro Medrano John Gordon Hbkan Mellstedt Saxon Graham Rob Michalides Bernd Groner John Morten Hans Schreiber ADVANCES IN CANCERRESEARCH Edited by GEORGE KLEIN Department of Tumor Biology Karolinska lnstitutet Stockholm. Sweden SIDNEY WEINHOUSE Fels Research Institute Temple University Medical School Philadelphia, Pennsylvania Volume 41-7984 ACADEMIC PRESS, INC. (Harcourt Brace Jovanovich, Publishers) Orlando San Diego San Francisco New York London Toronto Montreal Sydney Tokyo SBo Paulo COPYRIGHT @ 1984, BY ACADEMIC PRESS,INC. ALL RIGHTS RESERVED. NO PART OF THIS PUBLICATION MAY BE REPRODUCED OR TRANSMITTED IN ANY FORM OR BY ANY MEANS, ELECTRONIC OR MECHANICAL, INCLUDING PHOTOCOPY, RECORDING, OR ANY INFORMATION STORAGE AND RETRIEVAL SYSTEM, WITHOUT PERMISSION IN WRITING FROM THE PUBLISHER. ACADEMIC PRESS,INC. Orlando, Florida 3 2 8 8 7 United Kingdom Edition pitblislied by ACADEMIC PRESS, INC. ( L O N D O N ) LTD. 24/28 Oval Road, London NWI 7DX LIBRARY OF CONGRESS CATALOG CARDNUMBER: 52- I 3360 ISBN 0-12-006641-6 PRINTED IN THE UNITED STATES OF AMERICA 84 85 86 87 9 I! 7 6 5 4 3 2 1 CONTENTS CONTRIBUTOHS TO VOLUME 4 1 , ... .. .. . .. .. . .. . ... ix The Epidemiology of Diet and Cancer T I MBYEHSA N D SAXONG H A I I A M I. Introduction . . . . ..... .......... 11. Methods of Inquiry . , . . . , . . . . . . . . . . . . , . . . . , , , , . . . . . . . . . . . . . , . , . , . , . . , . 111. Methods of Measurement of Diet. . . . . . . . . ........... IV. A Review of Dietary Factors and Cancer Etiology by Si t e.. . . . . . . . . . . . , . . , . V. Conclusions. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . References ............. ............... 1 7 37 42 59 61 Molecular Aspects of Immunoglobulin Expression by Human B Cell Leukemias and Lymphomas JoirN GORDON I. 11. 111. Common Acute Lymphoblastic Leukemia: A Model for Pre-B Development .. . ... .. . IV. Burkitt Lymphoma and Related Tumors . . . . . . . . . . . . . . . . . . . . . . V. The Chronic Type Lymphocytic Leukemias: Models of Small Resting B Lymphocytes . . , . , . . , . , . . . . . . . . , . , . , . , . , . . . . . . . . . . . . . . . . . . . . . . . . . . . VI. Hairy Cell Leukemia: A Proliferation of Immunoglobulin Synthesizing Cells . . VII. The Processing of Immunoglobulins by Cells of Non-Hodgkin Lymphoina . . . . VIII. Induced Changes in the Phenotypic Expression of Inimunoglobulin by Neoplastic Cells , , , . , . . , . . . . . . . . . . . . . . . . . . . . . IX. Toward a Unifying Concept of the B Cell Neoplasia . . . . . . . . . . . . . . . . . . . . . . . References. . . . . . . . . . . . . . t , 72 74 87 90 95 109 114 121 128 147 Mouse Mammary Tumor Virus: Transcriptional Control and Involvement in Tumorigenesis NANCYE. HYNES,BEHNDGHONEH,A N V ROB M I C I I A L I I X S I . Introductioii . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . , . . . . .. . . . . . . . . . . . . . . . . . 11. Background. . . . . . . , . . . , , . . . . . . . . . . , . , . , , , , , , , , . . . . . . . . . . . . . . . . . . . . . . . V 155 156 vi CONTENTS MMTV Expression i l l Cli hlice. . , . .............................. .. .. . . . , . , . . . . . . . , . . . . . .. ..