E-Book Overview
The vast expansion in research on tumorigenesis has greatly increased our understanding of tumor development in patients with inherited endocrine tumor syndromes. This book provides an up-to-date summaryfrom clinical basics and latest follow-up guidelines to the most recent molecular findings in multiple endocrine neoplasia Type I syndrome. Articles have been assembled by acknowledged experts in their respective fields to provide current perspectives on the clinical and genetic backgroundsofthis syndrome and to review carefully the latest discoveries concerning the possible functions and interactions ofmenin, the protein encoded by the MEN1gene,including itspossible role incell cycle regulation,hematopoiesis,and bone development. The goal ofthe book is also to present the most recent findings and the broadest aspects of the role of menin in tumorigenesis of the endocrine glands involved in MEN I syndrome (pituitary, parathyroid, endocrine pancreas and adrenal). The connection between the basic experimental and clinical points of view are highlighted through a discussion on animal models, which explores the field in both an inspiring and questioning manner with a focus on areas that remain to be clarified. Our goal was to bring together clinicians and basic researchers who represent a wide range of interests in this particular field of endocrine oncology. Presentingacomprehensive and current overviewofbasic experimental and clinical findings, this book can bring us closer to understanding endocrine tumorigenesis in multiple endocrine neoplasia Type I. Katalin Balogh, MD, PhD Attita Patocs, MD, MSc, PhD v ABOUT THEEDITORS. . .
E-Book Content
SuperMEN!
ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY EditorialBoard: NATHAN BACK, State UniversityofNew York at Buffalo IRUN R. COHEN, The Weizmann Institute ofScience ABELLAJTHA, N.S. KlineInstitutefor PsychiatricResearch JOHN D. LAMBRIS, University ofPennsylvania RODOLFOPAOLETTI, UniversityofMilan Recent Volumes in this Series Volume 660 PARAOXONASES IN INFLAMMATION, INFECTION, AND TOXICOLOGY Edited by Srinu Reddy Volume 661 MEMBRANE RECEPTORS, CHANNELS ANDTRANSPORTERS IN PULMONARY CIRCULATION Edited by Jason X.-J. Yuan,and Jeremy P.T. Ward Volume 662 OXYGENTRANSPORT TO TISSUEXXXI Edited by Duane F. Bruley,and Eiji Takahasi Volume 663 STRUCTURE AND FUNCTION OF THE NEURALCELLADHESION MOLECULE NCAM Edited by Vladimir Berezin Volume 664 RETINALDEGENERATIVE DISEASES Edited by RobertE. Anderson,Joe G. Hollyfield,and MatthewM. LaVail Volume 665 FORKHEAD TRANSCRIPTION FACTORS Edited by KennethMaiese Volume 666 PATHOGEN-DERIVED IMMUNOMODULATORY MOLECULES Edited by PadraicG. Fallon Volume 667 LIPID A IN CANCERTHERAPY Edited by Jean-Francois Jeannin Volume 668 SUPERMEN I Edited by KataIin Balogh, and Attila Patocs AContinuation Order Plan isavailable forthisseries. Acontinuation orderwillbring delivery ofeachnewvolume immediately upon publication. Volumes are billed onlyuponactual shipment. For further information please contact thepublisher.
SuperMEN!: Pituitary, Parathyroid and Pancreas Edited by
Katalin Balogh, MD, PhD 2nd Department ofMedicine, Faculty ofMedicine , Semmelweis University, Budapest, Hungary
Attila Patocs, MD, MSc, PhD Hungarian Academy ofSciences Molecular Medicin e Research Group and 2nd Department ofMedicine , Faculty ofMedicine , Semmelweis University Budapest, Hungary
Springer Science+Business Media, LLC Landes Bioscience
Springer Science+Business Media,LLC LandesBioscience Copyright©2009 LandesBioscience and SpringerScience+Business Media, LLC All rights reserved. No partof thisbookmaybereproduced ortransmittedinanyformor byanymeans,electronic or mechanical, includingphotocopy, recording, or any informationstorageand retrievalsystem,withoutpermission in writingfromthe publisher, with the exceptionof any materialsuppl