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The renaissance of liquid chromatography took place in the late 1960's and early 1970's. The first edition of this book published in 1977 described the detectors that were available at that time and which provided a performance matching that of the contemporary equipment with which they were associated. It is interesting to note that the most popular detectors then (the UV detector, the refractometer detector, the fluorescence detector and the electrical conductivity detector) are still the most commonly used detectors nearly a decade later. Detector design, however, has changed very significantly over the intervening years. Modern high efficiency columns provide very narrow peaks and very fast separations, and thus the physical design of the detectors had to change to meet these new challenges. In 1977, there was little real understanding of the important role played by the detector in the overall function of the chromatographic system and although some of the factors were pointed out in the first edition of this book, in retrospect they appeared to be little understood. This second edition gives an entirely new presentation of the subject of liquid chromatography detectors.
E-Book Content
JOURNAL OF CHROMATOGRAPHY LIBRARY
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Volume 33
liquid chromatography detectors second, completely revised edition
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JOURNAL OF CHROMATOGRAPHY LIBRARY
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volume 33
liquid chromatography detectors second, completely revised edition
RJ?W Scott Perkin-Elmer Corporation, Instrument Group, Main A venue, Norwalk, CT 06859-0089, U.S.A.
ELSEVl ER Amsterdam - Oxford
- New York - Tokyo
1986
ELSEVIER SCIENCE PUBLISHERS B.V. Sara Burgerhartstraat 25 P.O. Box 211,1000 AE Amsterdam, The Netherlands Distributors for the United States and Canada: ELSEVIER SCIENCE PUBLISHING COMPANY INC. 52, Vanderbilt Avenue New York, NY 10017, U.S.A.
Library of Congrew Catdogin~inPublicatiollData
Scott, Raymond P . W . (Raymond Peter William), 1924Liquid chromatography detectors.
(Journal of chromatography library ; v. 33) Bibliography: p. Includes index. 1. Liquid chromatopaphy. I. T i t l e . 11. Series.
QW9. C454S36 1986 543'.0897 86-2045 ISBN 6444-426168 (Elsevier Science) ISBN 0-444-42610-8(Val. 33) ISBN 0-444-41616-1(Series)
0 Elsevier Science Publishers B.V.. 1986 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without the prior written permission of the publisher, Elsevier Science Publishers B.V./Science & Technology Division, P.O. Box 330,1000 AH Amsterdam, The Netherlands.
Special regulations for readers in the USA - This publication has been registered with the Copyright Clearance Center Inc. (CCC), Salem, Massachusetts. Information can be obtained from the CCC about conditions under which photocopies of parts of this publication may be made in the USA. All other copyright questions, including photocopying outside of the USA, should be referred to the publisher. Printed in The Netherlands
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. . . . . . . . . . . . . . . . . . XI PREFACE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . XV A C W V . . . . . . . . . . . . . . . . . . . . . . . . . . . XVI CHAPTER 1. HISTORY. FURCTION MID CLASSIFICATION OF DETECTORS . . . . .1 JOIJRIUL OF CBROWATOClUHlY LIBRARY
History and Function
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C l a s s i f i c a t i o n of Detectors
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............................ References . . . . . . . . . . . . . . . . . . . . . . . . . . . Synopsis
CHAPTER 2
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6 6
. PERFORMA