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ADVANCES IN CANCER RESEARCH VOLUME 53
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ADVANCES IN CANCER RESEARCH Edited by
GEORGE F. VANDE WOUDE NCI-Frederick Cancer Research Facility Frederick, Maryland
GEORGE KLEIN Department of Tumor Biology Karolinska lnstitutet Stockholm, Sweden
Volume 53
ACADEMIC PRESS, INC. Harcourt Brace Jovanovlch, Publirhers
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COPYRIGHT 0 1989 BY ACADEMIC PRESS, INC. All Rights Reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher.
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CONTENTS
CONTRIBUTORS TO VOLUME5 3 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
ix
Serum-inducible Genes
BARRETTJ. ROLLINS AND CHARLES D. STILES I. Introduction .................. 11. History: The .......................... 111. Biochemistry: The Role of Transcription and Translation in the Mitogenic Response to Serum .............. IV. Molecular Biology: Serum-Inducible Genes and Their Products . . . . . . . . . . . . . . V. Perspectives . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . VI. Addendum.. . . . . . . .... ................ References . . . . . . . . .... ................
1 3 5
8 21 22 25
Malaria, Epstein-Barr Virus, and the Genesis of Lymphomas CHRISTINE I. 11. 111. IV. V.
A. FACER AND J. H.L. PLAYFAIR
Introduction ................................ The Epstein-Barr Virus . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Burkitt’s Lymphoma Malaria . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Malaria and the Immune System
...............................
34 46
68
A Review of Kaposi’s Sarcoma JANE
I. 11. 111. IV.
ARMES
Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Clinical Features and Epidemiology of Kaposi’s Sarcoma ..................... Pathology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Cell of Origin of KS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . V
73 73 76 76
vi
CONTENTS
Neoplasm or Hyperplasia? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . V. KS . VI . Etiology of KS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . VII . Conclusion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
79
80 85 85
The Relationship between MHC Antigen Expression and Metastasis JACOB
GOPAS.BRACHARAGER.ZISMAN. MENASHEBAR.ELI. GUNTERJ . HAMMERLING. AND SHRAGA SEGAL
89 I . Introduction . .