Molecular Mechanisms In Gastrointestinal Cancer

C O M PA N Y R.G. LANDES MEDICAL INTELLIGENCE UNIT 12 B. Mark Evers EVERS Molecular Mechanisms in Gastrointestinal Cancer MIU 12 Molecular Mechanisms in Gastrointestinal Cancer R.G. LANDES COM PA N Y MEDICAL INTELLIGENCE UNIT 12 Molecular Mechanisms in Gastrointestinal Cancer B. Mark Evers, M.D. The University of Texas Medical Branch at Galveston Department of Surgery Galveston, Texas, U.S.A. R.G. LANDES COMPANY AUSTIN, TEXAS U.S.A. MEDICAL INTELLIGENCE UNIT Molecular Mechanisms in Gastrointestinal Cancer R.G. LANDES COMPANY Austin, Texas, U.S.A. Copyright ©1999 R.G. Landes Company All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Printed in the U.S.A. Please address all inquiries to the Publishers: R.G. Landes Company, 810 South Church Street, Georgetown, Texas, U.S.A. 78626 Phone: 512/ 863 7762; FAX: 512/ 863 0081 ISBN: 1-57059-590-0 While the authors, editors and publisher believe that drug selection and dosage and the specifications and usage of equipment and devices, as set forth in this book, are in accord with current recommendations and practice at the time of publication, they make no warranty, expressed or implied, with respect to material described in this book. In view of the ongoing research, equipment development, changes in governmental regulations and the rapid accumulation of information relating to the biomedical sciences, the reader is urged to carefully review and evaluate the information provided herein. Library of Congress Cataloging-in-Publication Data Molecular mechanisms in gastrointestinal cancer / edited by B. Mark Evers. p. cm. -- (Medical intelligence unit) ISBN 1-57059-590-9 (alk. paper) 1. Gastrointestinal system--Cancer--Molecular aspects. I. Evers, B. Mark, 1957-. II. Series. RC280.D5M635 1999 616.99'43307--dc21 98-43469 CIP MEDICAL INTELLIGENCE UNIT 12 PUBLISHER’S NOTE Molecular Mechanisms in Gastrointestinal Cancer Landes Bioscience produces books in six Intelligence Unit series: Medical, Molecular Biology, Neuroscience, Tissue Engineering, Biotechnology and Environmental. The authors of our books are acknowledged leaders in their fields. Topics are unique; almost without exception, no similar books exist on these topics. Our goal is to publish books in important and rapidly changing areas of bioscience for sophisticated researchers and clinicians. To achieve this goal, we have accelerated our publishing program to conform to the fast pace at which information grows in bioscience. Most of our books are within Branch 90 to 120atdays of receipt of The University ofpublished Texas Medical Galveston the manuscript. WeDepartment would like to thank our readers for their of Surgery continuing interest Galveston, and welcomeTexas, any comments U.S.A. or suggestions they may have for future books. B. Mark Evers, M.D. Michelle Wamsley Production Manager R.G. Landes Company R.G. LANDES COMPANY AUSTIN, TEXAS U.S.A. CONTENTS 1. Growth Factors, Hormones and Receptors in GI Cancers ..................... 1 B. Mark Evers and Courtney M. Townsend, Jr. Growth Factors ........................................................................................ 1 GI Hormones and Receptors ........................................................