E-Book Overview
Research indicates that most neurodegenerative diseases, systemic amyloidoses and many others, arise from the misfolding and aggregation of an underlying protein. This is the first book to discuss significant achievements in protein structure-function relationships in biochemistry, molecular biology and molecular medicine. The authors summarize recent progress in the understanding of the relationships between protein misfolding, aggregation and development of protein deposition disorders.
E-Book Content
Protein Misfolding, Aggregation, and Conformational Diseases
PROTEIN REVIEWS Editorial Board: EDITOR-IN-CHIEF: M. ZOUHAIR ATASSI, Baylor College of Medicine, Houston, Texas EDITORIAL BOARD: LAWRENCE J. BERLINER, University of Denver, Denver, Colorado ROWEN JUI-YOA CHANG, University of Texas, Houston, Texas HANS JÖRNVALL, Karolinska Institutet, Stockholm, Sweden GEORGE L. KENYON, University of Michigan, Ann Arbor, Michigan BRIGITTE WITTMAN-LIEBOLD, Wittman Institute of Technology and Analysis, Tetlow, Germany
Recent Volumes in this Series VIRAL MEMBRANE PROTEINS: STRUCTURE, FUNCTION, AND DRUG DESIGN Edited by Wolfgang B. Fischer THE p53 TUMOR SUPPRESSOR PATHWAY AND CANCER Edited by Gerard P. Zambetti PROTEOMICS AND PROTEIN-PROTEIN INTERACTIONS: BIOLOGY, CHEMISTRY, BIOINFORMATICS, AND DRUG DESIGN Edited by Gabriel Waksman PROTEIN MISFOLDING, AGGREGATION AND CONFORMATIONAL DISEASES PART A: PROTEIN AGGREGATION AND CONFORMATIONAL DISEASES Edited by Vladimir N. Uversky and Anthony L. Fink
A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumes are billed only upon actual shipment. For further information please contact the publisher.
Protein Misfolding, Aggregation, and Conformational Diseases Part A: Protein Aggregation and Conformational Diseases
Edited by
VLADIMIR N. UVERSKY Department of Biochemistry and Molecular Biology, and the Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana; Institute for Biological Instrumentation, Russian Academy of Sciences, Pushchino, Moscow Region, Russia
ANTHONY L. FINK Department of Chemistry and Biochemistry, University of California, Santa Cruz, California
Vladimir N. Uversky Department of Biochemistry and Molecular Biology Center for Computational Biology and Bioinformatics Indiana University School of Medicine Indianapolis, IN 46202 and Institute for Biological Instrumentation Russian Academy of Sciences Pushchino, Moscow Region 142290 Russia
Anthony L. Fink Department of Chemistry and Biochemistry University of California Santa Cruz, CA 95064 USA
Library of Congress Control Number: 2005926771 ISBN-10: 0-387-25918-X ISBN-13: 978-0387-25918-5 Printed on acid-free paper. © 2006 Springer Science+Business Media, Inc. All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, Inc., 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed in Singapore. 9
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Contents
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