E-Book Overview
Powerful new tools are now available to discover and understand tumor suppressor genes (TSGs) and the biochemical mechanisms by which they control cancer development and progression. In Tumor Suppressor Genes, Volume 1: Pathways and Isolation Strategies, leading physician scientists and academic researchers review all the known tumor suppressor genes, explain how they work, and describe how they were discovered and isolated. In many cases, the authors discuss specific genes that are frequently involved in hereditary or sporadic cancers. They also provide a detailed guide to using powerful molecular genetic, cytogenetic, proteomic, and cell biological strategies to isolate and characterize novel tumor suppressor genes and their targets. The companion volume of this set, Tumor Suppressor Genes, Volume 2: Regulation, Function, and Medicinal Applications, demonstrates how best to explore the cell biology and biochemical function of such genes, and their encoded proteins, to study their physiological role in vivo, and to use information on TSGs to develop diagnostic and therapeutic strategies for cancer. Comprehensive and authoritative, the two volumes of Tumor Suppressor Genes provide an unparalleled compilation of key data on all known tumor suppressor pathways and a treasury of techniques for their discovery, analysis, and uses in cancer therapeutics.
E-Book Content
Methods in Molecular Biology TM TM VOLUME 222 Tumor Suppressor Genes Volume I Pathways and Isolation Strategies Edited by Wafik S. El-Deiry, MD, PhD 1 Growth Control by the Retinoblastoma Gene Family Marco G. Paggi, Armando Felsani, and Antonio Giordano 1. Introduction 1.1. The Retinoblastoma Gene Family The Retinoblastoma family consists of three genes, RB, p107, and Rb2/p130, all fundamental in the control of important cellular phenomena, such as cell cycle