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Other Pergamon Titles of Related Interest ANANCHENKO Frontiers of Bioorganic Chemistry and Molecular Biology BAZAN Neurochemistry of the Retina KUMAR Biochemistry of Brain PASQUALINI Recent Advances in Steroid Biochemistry ROSS & GUDER Biochemical Aspects of Renal Function SARIN & GALLO Inhibitors of DNA and RNA Polymerases SARMA Nucleic Acid Geometry and Dynamics SRINIVASAN Biomolecular Structure, Conformation, Function and Evolution STEC Phosphorus Chemistry Directed towards Biology TORCHINSKY Sulfur in Proteins Related Pergamon Journals* Biochemical Education Biochemical Pharmacology Cellular and Molecular Biology Comparative Biochemistry and Physiology International Journal of Biochemistry Journal of Steroid Biochemistry Progress in Biophysics and Molecular Biology *Free spec/men copy of any journal available on request. Please write to your nearest Pergamon office for further details on any of the above books or journals. Medicinal Chemistry Advances Proceedings of the Seventh International Symposium on Medicinal Chemistry, Torremolinos, Spain 2 - 5 September 1980 Edited by FEDERICO G. DE LAS HERAS and SALVADOR VEGA Institute* de Qu/mica Medica, Madrid, Spain PERGAMON PRESS OXFORD · NEW YORK ■ TORONTO ■ SYDNEY ■ PARIS ■ FRANKFURT U.K. Pergamon Press Ltd., Headington Hill Hall, Oxford 0 X 3 OBW, England U.S.A. Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, New York 10523, U.S.A. CANADA Pergamon Press Canada Ltd., Suite 104, 150 Consumers Rd., Willowdale, Ontario M2J 1P9, Canada AUSTRALIA Pergamon Press (Aust.) Pty. Ltd., P.O. Box 544, Potts Point, N.S.W. 2011, Australia FRANCE Pergamon Press SARL, 24 rue des Ecoles, 75240 Paris, Cedex 05, France FEDERAL REPUBLIC OF GERMANY Pergamon Press GmbH, 6242 Kronberg-Taunus, Hammerweg 6, Federal Republic of Germany Copyright © 1981 Pergamon Press Ltd. All Rights Reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means: electronic, electrostatic, magnetic tape, mechanical, photocopying, recording or otherwise, without permission in writing from the publishers. First edition 1981 British Library Cataloguing in Publication Data International symposium on Medicinal Chemistry (Chemistry : 7th : 1980: Torremolinos) Medicinal chemistry advances. 1. Drugs - Congresses I. Title II. Heras, Federico G, de las III. Vega,Salvador 615'. 1 RM300 ISBN 0-08-025297-4 In order to make this volume available as economically and as rapidly as possible the authors' typescripts have been reproduced in their original forms. This method unfor tunately has its typographical limitations but it is hoped that they in no way distract the reader. Printed in Great Britain by A. Wheaton Et Co. Ltd., Exeter List of Contributors R. Acher Laboratory of Biological Chemistry University of P a r i s VI 96, Boulevard Raspail 7 5006 P a r i s , F r a n c e . M.A. Alonso Departamento de Microbiologia Centro de Biologia Molecular Universidad Autonoma Canto Blanco, Madrid-34, Spain. E . J . Ariens Institute of Pharmacology and Toxicology University of Nijmegen Geert Grooteplein N 21 P . O . Box 9101 6500 HB Nijmegen, The Netherlands. C. Arnau Facultat de Medicina Universität Autonoma de Barcelona B e l l a t e r r a , Barcelona, Spain. G. Bartholini Synthelabo ( L . E . R . S . ) 58, rue de la Glaciere 75013 P a r i s , F r a n c e . J. Benveniste INSERM U 200 Clamart/Paris, France. A. B e r e s Division of Medicinal Chemistry and Natural Products College of P h a r m a c y The University of Iowa Iowa City, Iowa 52242, U . S . A . D. Brandenburg Deutsches Wollforschungsinstitut Aachen, F e d e r a l Republic of Germany. J. H. Burc