Pocket Medicine: The Massachusetts General Hospital Handbook Of Internal Medicine (pocket Notebook Series)

LWBK634_FM[i-x].qxd 7/6/10 10:03PM Page i Aptara Inc POCKET N OT E B O O K Pocket MEDICINE Fourth Edition Edited by MARC S. SABATINE, M.D., M.P.H. ASSOCIATE PROFESSOR OF MEDICINE HARVARD MEDICAL SCHOOL The Massachusetts General Hospital Handbook of Internal Medicine LWBK634_FM[i-x].qxd 7/6/10 10:03PM Page ii Aptara Inc Acquisitions Editor: Sonya Seigafuse Product Manager: Kerry Barrett Production Manager: Bridgett Dougherty Senior Manufacturing Manager: Benjamin Rivera Marketing Manager: Kim Schonberger Design Coordinator: Doug Smock Production Service: Aptara © 2011 by LIPPINCOTT WILLIAMS & WILKINS, a WOLTERS KLUWER business Two Commerce Square 2001 Market Street Philadelphia, PA 19103 USA LWW.com All rights reserved.This book is protected by copyright. No part of this book may be reproduced in any form by any means, including photocopying, or utilized by any information storage and retrieval system without written permission from the copyright owner, except for brief quotations embodied in critical articles and reviews. Materials appearing in this book prepared by individuals as part of their official duties as U.S. government employees are not covered by the above-mentioned copyright. Printed in China Library of Congress Cataloging-in-Publication Data Pocket medicine / edited by Marc S. Sabatine.–4th ed. p. ; cm. “The Massachusetts General Hospital Handbook of Internal Medicine.” Includes bibliographical references and index. ISBN-13: 978-1-60831-905-3 (domestic : alk. paper) ISBN-10: 1-60831-905-9 (domestic : alk. paper) ISBN-13: 978-1-4511-0335-9 (international : alk. paper) ISBN-10: 1-4511-0335-2 (international : alk. paper) 1. Internal medicine–Handbooks, manuals, etc. I. Sabatine, Marc S. II. Massachusetts General Hospital. [DNLM: 1. Internal Medicine–Handbooks. 2. Clinical Medicine–Handbooks. WB 39 P7394 2011] RC55.P63 2011 616–dc22 2010024523 DISCLAIMER Care has been taken to confirm the accuracy of the information presented and to describe generally accepted practices. However, the authors, editors, and publisher are not responsible for errors or omissions or for any consequences from application of the information in this book and make no warranty, expressed or implied, with respect to the currency, completeness, or accuracy of the contents of the publication. Application of the information in a particular situation remains the professional responsibility of the practitioner. The authors, editors, and publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accordance with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions.This is particularly important when the recommended agent is a new or infrequently employed drug. Some drugs and medical devices presented in the publication have Food and Drug Administration (FDA) clearance for limited use in restricted research settings. It is the responsibility of the health care provider to ascertain the FDA status of each drug or device planned for use in their clinical practice. To purchase additional copies of this book, call our customer service department at (800) 638-3030 or fax orders to (301) 223-2320. International customers should call (301) 223-2300. Visit L