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1This collection of review articles highlights the latest development of antithrombotics and provides proven experimental methods for the further development of new and improved anticoagulants. Among the cutting-edge developments reviewed are the novel usage of low molecular weight heparins, such antithrombin agents as the hirudin, and such antiplatelet drugs as the GPIIb/IIIa inhibitors and ADP receptor antagonists. Additional innovations discussed include aspirin and clopidogrel, the expanded use of polytherapeutic approaches, antiproteases (factors IIa, Xa, and VIIa), tissue factor targeting, platelet receptor targeting, and antithrombin III modulation.
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M E T H O D S I N M O L E C U L A R M E D I C I N E TM Anticoagulants, Antiplatelets, and Thrombolytics Edited by Shaker A. Mousa Anticoagulants, Antiplatelets, and Thrombolytics M E T H O D S I N M O L E C U L A R M E D I C I N E™ John M. Walker, SERIES EDITOR 96. Hepatitis B and D Protocols: Volume 2, Immunology, Model Systems, and Clinical Studies, edited by Robert K. Hamatake and Johnson Y. N. Lau, 2004 95. Hepatitis B and D Protocols: Volume 1, Detection, Genotypes, and Characterization, edited by Robert K. Hamatake and Johnson Y. N. Lau, 2004 94. Molecular Diagnosis of Infectious Diseases, Second Edition, edited by Jochen Decker and Udo Reischl, 2004 93. Anticoagulants, Antiplatelets, and Thrombolytics, edited by Shaker A. Mousa, 2004 92. Molecular Diagnosis of Genetic Diseases, Second Edition, edited by Rob Elles and Roger Mountford, 2003 91. Pediatric Hematology: Methods and Protocols, edited by Nicholas J. Goulden and Colin G. Steward, 2003 81. Prostate Cancer Methods and Protocols, edited by Pamela J. Russell, Paul Jackson, and Elizabeth A. Kingsley, 2003 80. Bone Research Protocols, edited by Miep H. Helfrich and Stuart H. Ralston, 2003 79. Drugs of Abuse: Neurological Reviews and Protocols, edited by John Q. Wang, 2003 78. Wound Healing: Methods and Protocols, edited by Luisa A. DiPietro and Aime L. Burns, 2003 77. Psychiatric Genetics: Methods and Reviews, edited by Marion Leboyer and Frank Bellivier, 2003 76. Viral Vectors for Gene Therapy: Methods and Protocols, edited by Curtis A. Machida, 2003 75. Lung Cancer: Volume 2, Diagnostic and Therapeutic Methods and Reviews, edited by Barbara Driscoll, 2003 90. Suicide Gene Therapy: Methods and Reviews, edited by Caroline J. Springer, 2003 74. Lung Cancer: Volume 1, Molecular Pathology Methods and Reviews, edited by Barbara Driscoll, 2003 89. The Blood–Brain Barrier: Biology and Research Protocols, edited by Sukriti Nag, 2003 73. E. coli: Shiga Toxin Methods and Protocols, edited by Dana Philpott and Frank Ebel, 2003 88. Cancer Cell Culture: Methods and Protocols, edited by Simon P. Langdon, 2003 72. Malaria Methods and Protocols, edited by Denise L. Doolan, 2002 87. Vaccine Protocols, Second Edition, edited by Andrew Robinson, Michael J. Hudson, and Martin P. Cranage, 2003 71. Haemophilus influenzae Protocols, edited by Mark A. Herbert, Derek Hood, and E. Richard Moxon, 2002 86. Renal Disease: Techniques and Protocols, edited by Michael S. Goligorsky, 2003 70. Cystic Fibrosis Methods and Protocols, edited by William R. Skach, 2002 85. Novel Anticancer Drug Protocols, edited by John K. Buolamwini and Alex A. Adjei, 2003 69. Gene Therapy Protocols, Second Edition, edited by Jeffrey R. Morgan, 2002 84. Opioid Research: Methods and Protocols, edited by Zhizhong Z. Pan, 2003 68. Molecular Analysis of Cancer, edited by Jacqueline Boultwood and Carrie Fidler, 2002 83. Diabetes Mellitus: Methods and Protocols, edited by Sabire Özcan, 2003 82. Hemoglobin Disorders: Molecular Methods and Protocols, edited by Ronald L. Nagel, 200