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This is a well-rounded handbook of fermentation and biochemical engineering presenting techniques for the commercial production of chemicals and pharmaceuticals via fermentation. Emphasis is given to unit operations fermentation, separation, purification, and recovery. Principles, process design, and equipment are detailed. Environment aspects are covered. The practical aspects of development, design, and operation are stressed. Theory is included to provide the necessary insight for a particular operation. Problems addressed are the collection of pilot data, choice of scale-up parameters, selection of the right piece of equipment, pinpointing of likely trouble spots, and methods of troubleshooting. The text, written from a practical and operating viewpoint, will assist development, design, engineering and production personnel in the fermentation industry. Contributors were selected based on their industrial background and orientation. The book is illustrated with numerous figures, photographs and schematic diagrams.
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FERMENTATION AND BIOCHEMICAL ENGINEERING HANDBOOK Second Edition FERMENTATION AND BIOCHEMICAL ENGINEERING HANDBOOK Principles, Process Design, and Equipment Second Edition Edited by Henry C. Vogel Consultant Scotch Plains, New Jersey and Celeste L. Todaro Heinkel Filtering Systems, Inc. Bridgeport, New Jersey NOYES PUBLICATIONS Westwood, New Jersey, U.S.A. Copyright © 1997 by Noyes Publications No part of this book may be reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording or by any information storage and retrieval system, without permission in writing from the Publisher. Library of Congress Catalog Card Number: 96-29055 ISBN: 0-8155-1407-7 Printed in the United States Published in the United States of America by Noyes Publications 369 Fairview Avenue, Westwood, New Jersey 07675 10 9 876 5 4 3 2 1 Library of Congress Cataloging-in-Publication Data Fermentation and biochemical engineering handbook. -- 2nd ed. / edited by Henry C. Vogel and Celeste L. Todaro. p. em. Includes bibliographical references and index. ISBN 0-8155-1407-7 1. Biochemical engineering--Handbooks, manuals, etc. 2. Fermentation--Handbooks, manuals, etc. I. Vogel, Henry C. II. Todaro, Celeste L. TP248.3.F74 1996 660'.28449--dc20 96-29055 CIP DEDICATION For my parents, Ernest and Charlotte Todaro, whose pursuit of knowledge inspired me and continues to do so. Preface to the Second Edition The second edition ofthe Fermentation andBiochemical Engineering Handbook, like the previous edition, is intended to assist the development, design and production engineer who is engaged in the fermentation industry. Particular emphasis is give to those unit operations nlost frequently encountered in the commercial production ofchemicals and pharmaceuticals via fermentation, separation, and purification. Some theory is included to provide the necessary insight into the unit operation but is not emphasized. Rather, the emphasis is placed on the practical aspects of development, design and operation-how one goes about collecting design data, what are the scale-up parameters, how to select the right piece of equipment, where operating problems arise, and how to troubleshoot. The text is written from a practical and operating viewpoint, and all of the contributing authors have been chosen because of their industrial background and orientation. Several of the chapters which were in the first edition have been either deleted or replaced by other chapters which are more germane to current fermentation practice. Those chapters which were retained have been updated or have been rewritten to reflect current practice. Several new chapters were introduced to reflect current emphasis on cel