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The series Cell Engineering is the first and only major reference work on the development of cellular systems for the production of recombinant glycoproteins, gene and cell therapies, drug screening and tissue engineering. This volume on "Apoptosis" is intended to review the state-of-the-art with in-depth assessments of this type of programmed cell death. The aim of the volume is to make the recent developments in apoptotic research readily accessible to biologists, biotechnologists and cellular engineers. The implication of apoptosis in the suppression of diseases and prolonging survival of cells in culture is presented to indicate the great potential of apoptotic research for drug production and the development of human therapies. All chapters are written as self-contained treatments of the important topics in apoptosis that are presented on an essential information basis. Topics covered range from understanding the role of signalling and effector molecules, mathematical modelling of cell death, RNAi tools in apoptosis research, to monitoring and imaging of apoptosis. This volume will be an invaluable resource for biotechnologists and researchers in apoptosis, cell biology, cell culture and molecular medicine.
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Cell Engineering Cell Engineering Volume 4 Editor-in-Chief Professor Mohamed Al-Rubeai School of Chemical Engineering, The University of Birmingham, Edgbaston, Birmingham, U.K. Editorial Board Dr Hansjorg Hauser GBF, Braunschweig, Germany Professor Michael Betenbaugh Johns Hopkins University, Baltimore, U.S.A. Professor Martin Fussenegger Swiss Federal Institute of Technology Zurich, Switzerland Dr Nigel Jenkins Bioprocess Research & Development, Lilly Research Laboratories, Indianapolis, U.S.A. Professor Caroline MacDonald University of Paisley, Paisley, U.K. Dr Otto-Wilhelm Merten A.F.M.-Genethon 11, Gene Therapy Program, Evry, France The titles published in this series are listed at the end of this volume CELL ENGINEERING Vol. 4: Apoptosis Edited by Mohammed Al-Rubeai School of Chemical Engineering, The University of Birmingham, Edgbaston, Birmingham, U.K. and Martin Fussenegger Swiss Federal Institute of Technology, Zurich, Switzerland KLUWER ACADEMIC PUBLISHERS NEW YORK, BOSTON, DORDRECHT, LONDON, MOSCOW eBook ISBN: Print ISBN: 1-4020-2217-4 1-4020-2216-6 ©2005 Springer Science + Business Media, Inc. Print ©2004 Kluwer Academic Publishers Dordrecht All rights reserved No part of this eBook may be reproduced or transmitted in any form or by any means, electronic, mechanical, recording, or otherwise, without written consent from the Publisher Created in the United States of America Visit Springer's eBookstore at: and the Springer Global Website Online at: http://ebooks.kluweronline.com http://www.springeronline.com CONTENTS LIST OF CONTRIBUTORS 1. CASPASE REGULATION AT THE MOLECULAR LEVEL H. Kaufmann and M. Fussenegger 2. THE BCL-2 FAMILY A. Petch and M. Al-Rubeai vii 1 25 3. THE IGF-1 RECEPTOR IN CELLS SURVIVAL: SIGNALLING AND REGULATION 49 P. A. Kiely, D. M. O’Gorman, A. Lyons and R. O’Connor 4. APOPTOSIS IN HEPATOCYTES N.T. Mukwena and M. Al-Rubeai 5. PROGRAMMED CELL DEATH IN PLANTS DURING DEVELOPMENT AND STRESS RESPONSES S. Panter and M. Dickman 6. A SYSTEMS VIEW OF CELL DEATH J. Varner and M. Fusseneger 7. THE ROLE OF CASPASES IN APOPTOSIS AND THEIR INHIBITION IN MAMMALIAN CELL CULTURE T. M. Sauerwald and. M.J. Betenbaugh 93 107 153 181 8. IMPROVEMENT OF INDUSTRIAL CELL CULTURE PROCESSES BY CASPASE- 9 DOMINANT NEGATIVE AND OTHER APOPTOTIC INHIBITORS 211 J. van de Goor 9. THERAPEUTIC SMALL MOLECULE INHIBITORS OF BCL-2 P. Beauparlant and G. C. Shore 223 vi 10. APO